Posts Tagged ‘biochemical patheays’

A potential biochemistry classic!

June 17, 2008

Coturnix alerts to a new paper in PLOS Biology on some basic issues of biochemistry:

A dozen or so years ago, I drove my Biochemistry prof to tears with questions – she had 200 people in front of her and she tried hard to make Biochem interesting enough not to get us all bored to tears, and she was pretty good at that, as much as it is possible not to make people bored to tears with Biochem. But my questions exasperated her mainly because she could not answer them, because, as I learned later, the field of biochemistry was not able to answer those questions yet at the time: questions about dynamics – how fast is a reaction, how long it takes for a pathway to go from beginning to end, how many individual molecules are synthesized per unit of time?, etc.

Well, the field is starting to catch up with my questions lately – adding the temporal dimension to the understanding of what is going on inside the cell. In today’s issue of PLoS Biology, there is a new article that is trying to address exactly this concern: Dynamics and Design Principles of a Basic Regulatory Architecture Controlling Metabolic Pathways.

Coturnix also points to an editorial synopsis that accompanies the paper, and goes on to say that the paper is a potential classic:

You should also check out the editorial synopsis for the paper, as it places it nicely into the context – exactly the kind of context I was looking for, in vein, back in my Biochem class: The Fourth Dimension of Biochemical Pathways.

… but perhaps in 10 years we’ll look at it and say “it’s a classic!”

Take a look!